GLN3 — Candida albicans

Summary

C5_04280C_A (GLN3) on Candida albicans chromosome 5 encodes a GATA-family transcription factor with sequence-specific DNA-binding and RNA polymerase II regulatory activity. The protein localises to the nucleus and is associated with nitrogen catabolite repression, urea metabolism, nitrate assimilation, and regulation of arginine breakdown and anabolism. It has been linked to morphogenesis, filamentous growth in response to starvation, chlamydospore formation, sporulation, and cellular responses to starvation. Studies of related genes in other species connect the family to reduced virulence and unaffected pathogenicity, though this has not been established for C. albicans GLN3.