PFK1 — Candida albicans

Summary

C5_04810W_A (PFK1) on Candida albicans chromosome 5 encodes a 6-phosphofructokinase, an enzyme that catalyzes the phosphorylation of fructose-6-phosphate in glycolysis. The gene product contains phosphofructokinase domains and binds ATP, AMP, and fructose-6-phosphate. PFK1 is associated with canonical glycolysis, carbohydrate breakdown, aerobic respiration, and cellular responses to glucose stimulus. It is linked to glucose and fructose metabolism, cellular chemical homeostasis, pH regulation, and vacuolar proton-transporting ATPase complex assembly. The gene is associated with phenotypic switching, micropexophagy, peroxisome localization, and mitochondrial outer membrane localization. Associations with traits include fermentative and anaerobic growth, carbon source utilization, cell cycle progression, replicative lifespan, prion inheritance, thermotolerance, desiccation resistance, and freeze-thaw resistance. Related genes in other species link the family to phosphate content and acid sensitivity.