FUR1 — Candida albicans

Summary

C5_03390C_A (FUR1, CaFUR1) on Candida albicans chromosome 5 encodes a uracil phosphoribosyltransferase (EC 2.4.2.9) with uridine kinase, cytidine kinase, ATP and GTP binding activities, belonging to the PRTase-like family. The gene is associated with uracil, CTP, UMP and pyrimidine salvage, pyrimidine base metabolism, xenobiotic and sterol metabolism, ergosterol anabolism, mating, and fermentation. It is linked to the fungal biofilm matrix, mitotic spindle pole body, cell division site, cytoplasm, cytosol and nucleus. Associations include decreased invasive and pseudohyphal growth, decreased mating efficiency, decreased acquired thermotolerance and ionic stress resistance, abnormal cell cycle progression (G1 arrest, altered duration, delayed M phase), increased polyploidy rate, delayed chromosome segregation, increased telomere length, abnormal nuclear morphology and sporulation, and altered prion inheritance. Studies of related genes in other species link the family to decreased filamentous and invasive growth and decreased oxidative stress resistance.