TRR1 — Candida albicans

Summary

C5_02710W_A (TRR1) in Candida albicans encodes a thioredoxin reductase with NADPH activity (EC 1.8.1.9), a FAD/NAD-binding oxidoreductase that also binds ferrous iron. The gene is associated with cell redox homeostasis, response to oxidative stress, programmed cell death, biofilm formation, hyphal growth, morphogenesis, and signal transduction. It is linked to mitochondrial, cytoplasmic, nuclear, and biofilm matrix localisation. TRR1 is associated with numerous phenotypes including altered cell cycle progression (increased G2/M transition rate, decreased S phase), increased aneuploidy, decreased radiation resistance, abnormal replicative lifespan, increased mutation frequency, altered fermentative metabolism, increased survival in stationary phase, and abnormal colony color. It is also associated with nutrient uptake changes, cold sensitivity, and redox state abnormalities. Related genes in other species link the family to thioredoxin-dependent redox regulation and oxidative stress resistance.