CLM2 — Aspergillus nidulans FGSC A4

Summary

AnCLM2 (ANIA_02727) on chromosome 6 of Aspergillus nidulans encodes a putative cytochrome P450 with heme binding, iron binding, and oxidoreductase activity acting on paired donors with incorporation of molecular oxygen. The gene is associated with ergosterol anabolism, patulin anabolism, terpenoid anabolism, secondary metabolite biosynthesis, lipogenesis, fermentation, sexual reproduction, meiosis, endocytosis, autophagy, and hypersensitivity. It is linked to the endoplasmic reticulum membrane. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; increased cell death and fermentative metabolism; abnormal cell cycle progression; arrested vegetative and exponential growth; and altered stress resistance, nutrient uptake, and lifespan. Studies of related genes in other species connect the family to sterol 14α-demethylase activity and protein content.