FOR — Aspergillus nidulans FGSC A4

Summary

ANIA_03058 (FOR) encodes a serine hydroxymethyltransferase with glycine hydroxymethyltransferase activity and pyridoxal phosphate binding, placing it in the Ser_HO-MeTrfase family. In Aspergillus nidulans, FOR is associated with tetrahydrofolate interconversion and metabolism, cell tip growth, hyphal growth, asexual sporulation, spore formation, signal transduction, cell cycle processes including interphase, nuclear division, cytokinesis, mitosis and meiosis, and localizes to mitochondria, cytoplasm, cytosol and the fungal biofilm matrix. Phenotypic associations link FOR to cell cycle progression, particularly S phase arrest and decreased progression, premature metaphase and telophase progression, abnormal cytokinesis, increased meiotic recombination, arrested meiosis, decreased colony size, abnormal cell size, increased budding and flocculation, altered budding patterns, decreased mitochondrial genome maintenance and rho- mutation frequency, absent respiratory metabolism, increased fermentative metabolism, and decreased prion inheritance and silencing. Studies of related genes in other species connect the family to nutrient utilization and turgor pressure.