mto1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03062 (mto1) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes an uncharacterized protein containing a PACT domain and a Cnn_1N domain. The gene is associated with spindle pole body anchor activity, calmodulin binding, and damaged DNA binding. It is linked to numerous mitotic processes, including astral microtubule nucleation, spindle pole body-led chromosome movement, mitotic spindle positioning and orientation, nuclear migration, and karyogamy. The product localizes to the central and outer plaques of the mitotic spindle pole body, the half bridge, the nucleus leading edge, and the Smc5-Smc6 complex. The gene is also associated with protein content. Related genes in other species, such as the spindle-pole body protein Pcp1, link the family to microtubule organization and nuclear movement.