PSD2 — Aspergillus nidulans FGSC A4

Summary

ANIA_03188 (symbol PSD2, also known as AnPSD2 or AnPSD3) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a phosphatidylserine decarboxylase (EC 4.1.1.65) with a C2 domain, EF-hand calcium-binding motifs, and phospholipid-binding activity. The gene product localises to Golgi, endosome, vacuolar and mitochondrial membranes, the cytosol and the cell division site. It is associated with protein autoprocessing, biofilm formation, filamentous growth in response to chemical, starvation and biotic stimuli, and with phosphatidylcholine anabolism. Phenotypic associations include altered colony size, abnormal pseudohyphal growth, defective cytokinesis, decreased budding, increased or decreased apoptosis, delayed or absent autophagy, decreased mitochondrial transport and genome maintenance, decreased nutrient uptake and utilisation, abnormal peroxisomal morphology, and altered fermentative metabolism. The gene is also linked to quantum yield.