NBS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03372, symbol NBS1 on chromosome 6 of Aspergillus nidulans FGSC A4, encodes a nibrin second BRCT domain-containing protein, a component of the MRN complex. The gene product is associated with damaged DNA binding and is linked to a wide range of DNA metabolism processes, including DNA repair, homologous recombination, the DNA damage response, and cell cycle checkpoints such as the mitotic G2 DNA damage checkpoint and the DNA replication checkpoint. NBS1 has also been connected to telomere maintenance, meiosis, anaphase, S phase, and DNA replication. Beyond genome maintenance, the gene is associated with hyphal growth, sporulation, and appressorium formation.