CREB — Aspergillus nidulans FGSC A4

Summary

ANIA_03587 (symbol CREB, also known as AnCREB) encodes a metal-dependent deubiquitinase (EC 3.4.19.12) belonging to the peptidase C19 and ubiquitin-specific protease families. In Aspergillus nidulans, this gene is associated with carbon catabolite repression, regulation of penicillin anabolism, response to carbon starvation, L-glutamate import, proline and acetate metabolism, sucrose breakdown, conidiophore development, germ tube formation, and regulation of protein stability. The encoded protein localizes to the cell tip, cell division site, cytosol, and nucleus. Phenotypic associations include increased G2/M cell cycle progression, increased fermentative metabolism and starvation resistance, but decreased osmotic and ionic stress resistance, decreased nutrient uptake, and arrested vegetative growth and exponential phase growth. Studies of related genes in other species link the family to oxidative stress response.