NIT2 — Aspergillus nidulans FGSC A4

Summary

ANIA_03656 (NIT2) on Aspergillus nidulans chromosome 2 encodes a putative nitrilase with a C-N hydrolase domain, possessing deaminated glutathione amidase, bis(5'-adenosyl)-triphosphatase, ω-amidase, and hydrolase activities on carbon-nitrogen bonds in linear amides. The gene is associated with nitrate metabolism, nitrogen catabolite repression, nitrate assimilation, nitrogen utilization, glutamine metabolism, diadenosine triphosphate breakdown, oxaloacetate metabolism, gibberellin biosynthesis, cellular detoxification, homologous recombination, and hyphal growth. It is linked to mitochondria, cytoplasm, and cytosol localization. Phenotypic associations include normal competitive fitness, absent respiratory growth, increased protein/peptide accumulation, decreased toxin resistance, abnormal and increased chemical compound accumulation, decreased competitive fitness, increased resistance to chemicals, and viability. Studies of related genes in other species link the family to hydrolase activity.