HIS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_03748 (HIS1, AnHIS1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes ATP phosphoribosyltransferase (EC 2.4.2.17), a HisG-family enzyme. The gene is annotated to histidine anabolism, ATP binding, magnesium binding, and cytoplasmic localisation. HIS1 is associated with a broad range of cellular and stress-related phenotypes, including abnormal mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy and mitophagy, delayed budding, altered colony and liquid culture appearance, increased biofilm formation, decreased nucleolus size, abnormal cell cycle progression, altered RNA and protein accumulation, increased cold sensitivity and metal resistance, decreased heat sensitivity, and both increased and decreased replicative and chronological lifespan. It is also linked to altered stress resistance, starvation resistance, nitrogen source utilisation, and transposable element transposition.