HEH2 — Aspergillus nidulans FGSC A4

Summary

ANIA_03910 (HEH2, AnHEH2) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a putative sister chromatid separation protein (Src1) that belongs to the Heh2/Src1 family and contains a MAN1 winged-helix domain, a HeH/LEM domain, and an MSC domain. The product is associated with chromatin binding and has been linked to nuclear inner membrane and nuclear periphery localization. It is associated with multiple cell cycle processes including mitosis, mitotic exit, cell cycle transition, interphase, and abscission, as well as nuclear membrane organization and nuclear transport. Phenotypic associations include abnormal or delayed cell cycle progression, delayed chromosome segregation, decreased mitotic and meiotic recombination, abnormal nuclear import and export, decreased nucleophagy, absent micronucleophagy, absent pheromone sensitivity, and sterility. Related genes in other species link the family to nuclear transport and cell cycle regulation.