bub1 — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene bub1 (ANIA_03946) on chromosome 2 encodes an uncharacterized protein with serine/threonine kinase activity, histone H2A kinase activity, and ubiquitin ligase inhibitor activity. It contains Mad3/Bub1 and protein kinase domains. The gene is associated with the spindle assembly checkpoint, mitotic checkpoint, and meiosis I spindle assembly checkpoint, as well as homologous chromosome segregation, centromeric meiotic sister chromatid cohesion, spindle orientation, and nuclear movement. Its product localises to the kinetochore, centromere, Bub1-Bub3 complex, MCC, and mitotic spindle pole body. The gene is linked to cell cycle modulation, mitosis, anaphase, and telophase. Studies of related genes in other species connect the family to germination rate and oxidative stress response.