GLIT — Aspergillus nidulans FGSC A4

Summary

ANIA_03963 (GLIT, AnGLIT) on Aspergillus nidulans chromosome 2 encodes a thioredoxin reductase GliT with oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen, also annotated as a monooxygenase with iron and heme binding. The gene is associated with gliotoxin anabolism and its regulation, mycotoxin anabolism, secondary metabolism, and kojic acid anabolism. It has been connected to cellular response to mycotoxin and toxic substances, cell redox homeostasis, detoxification, secretion, autolysis, cell death, and sulfur metabolism. The product is localized extracellularly. Studies of related genes in other species link the family to thioredoxin reductase (NADPH) activity (EC 1.8.1.9) and associations with plant pathogens such as Verticillium dahliae and Fusarium oxysporum.