SNF7 — Aspergillus nidulans FGSC A4

Summary

ANIA_04240, designated AnSNF7 (also known as AnVPS32), encodes a member of the Snf7 family of proteins. The product is associated with identical protein binding and localises to the ESCRT III complex, the endosome membrane, and the nuclear envelope. AnSNF7 has been linked to a wide range of cellular processes, including endosome-to-vacuole transport via the multivesicular body (MVB) sorting pathway, vesicle formation, mitotic nuclear membrane reassembly, filamentous growth in response to pH, and ER-phagy. It is also associated with cellular responses to lithium ions and ATP export. Phenotypic associations include vacuolar transport, endocytosis, autophagy, nucleophagy, biofilm formation, carbon source utilisation, and cell cycle progression. Studies of related genes in other species link the SNF7 family to turgor pressure and sensitivity to calcium and acid.