VAM3 — Aspergillus nidulans FGSC A4

Summary

ANIA_04416 (VAM3, AnVAM3) in Aspergillus nidulans FGSC A4 encodes a t-SNARE coiled-coil homology domain-containing protein with syntaxin and T_SNARE domains, and is associated with SNARE binding. This gene is associated with vacuole fusion, Golgi-to-vacuole transport, vesicle fusion, intracellular protein transport, hyphal growth, secretion, and endocytosis. The product localizes to the SNARE complex, late endosome, endomembrane system, fungal-type vacuole membrane, Golgi, and ER. Phenotypic associations include abnormal sporulation efficiency, absent vacuolar morphology, delayed protein transport, abnormal colony color, increased hydrostatic pressure resistance, increased alkaline pH and ionic stress resistance, abnormal autophagy, and increased entry into G0 phase. Studies of related genes in other species link the family to mitophagy and sensitivity to zinc, calcium, and oxidative stress.