LEU3 — Aspergillus nidulans FGSC A4

Summary

ANIA_04486 (LEU3, AnLEU3) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes a Zn(2)-C6 fungal-type domain-containing protein with DNA-binding transcription activator activity. The gene is associated with siderophore metabolism, regulation of cellular response to iron ion starvation, riboflavin transport, valine anabolism, cellular response to basic pH, cellular iron ion homeostasis, interaction with host, filamentous growth, autophagy, proteolysis, and DNA repair. It localises to both the cytoplasm and nucleus. Phenotypic associations include abnormal mitochondrial transport, absent meiosis, increased X-ray resistance, decreased pexophagy and mitophagy, increased silencing and flocculation, altered carbon source utilisation, arrested cell cycle progression, and abnormal nuclear morphology. Studies of related genes in other species link the family to reduced virulence and altered stress resistance, though these are not established for AnLEU3 itself.