HH1 — Aspergillus nidulans FGSC A4

Summary

ANIA_04564 (HH1, also known as teaA) encodes a protein membrane adaptor containing a Kelch-type beta-propeller domain. In Aspergillus nidulans, this gene is associated with conidiophore development, cell growth mode switching from monopolar to bipolar, regulation of cell shape, and establishment or maintenance of bipolar cell polarity. It is linked to spindle positioning, karyogamy, DNA replication checkpoint, microtubule assembly and dynamics, actin polymerization, exocytosis, and protein breakdown. The product localizes to microtubule ends, the Spitzenkörper, and growing cell tips. Studies of related genes in other species link the family to microtubule organization and cell polarity.