CHS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_04566 (CHS1, AnCHS1) on chromosome 3 encodes a chitin synthase with chitin synthase activity (EC 2.4.1.16), containing chitin synthase N-terminal domains. The gene is associated with cell septum assembly, septum positioning, regulation of chitin anabolism, conidiophore development, ascospore wall assembly, septum digestion after cytokinesis, ascospore formation, conidia formation, cell wall organization, hyphal growth, morphogenesis, and cell growth. The product localizes to the chitosome, hyphal tip, cross wall, cell periphery, and plasmalemma. Phenotypic associations include absent septum formation, abnormal chitin deposition, abnormal spore wall formation, decreased flocculation, absent cell fusion, abnormal bipolar budding, decreased adhesion, decreased cell death, and increased survival rate in stationary phase. Related genes in other species are linked to reduced virulence and vegetative growth defects.