PRF1 — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene AnPRF1 (ANIA_04570) on chromosome 3 encodes a putative RNA polymerase II transcription elongation factor Rtf1p, a Plus3 domain-containing protein that binds RNA polymerase II C-terminal domain phosphoserine, bubble DNA, single-stranded DNA, and RNA. It is a component of the Paf1 complex and localises to the nucleus. AnPRF1 is associated with the regulation of sterigmatocystin and mycotoxin biosynthesis, penicillin anabolism, secondary metabolism, sexual and asexual sporulation, hyphal growth, filamentous growth, mating, pheromone response, and morphogenesis. The gene has been linked to cell cycle progression through G1/S and G2/M phase transitions, mitotic and meiotic recombination, meiosis, UV resistance, transposable element transposition, pexophagy, lifespan, and sulfur source utilisation. Studies of related genes in other species connect the family to calcium and acid sensitivity, potassium concentration, and oxidative stress response.