CDC42 — Aspergillus nidulans FGSC A4

Summary

ANIA_04743 (CDC42) on chromosome 3 of Aspergillus nidulans encodes a small GTPase of the Rho family, also known as RacA. The product exhibits GTPase activity, GDP and GTP binding, and is annotated with protein serine/threonine kinase activator activity and signaling adaptor activity. CDC42 is associated with the regulation of cell morphogenesis, bipolar cell growth, and the switch between budding and filamentous growth. It is linked to cortical cytoskeleton organization, septin ring organization, and regulation of exocytosis and vesicle-mediated transport. The protein localizes to the hyphal tip polarisome, the Spitzenkörper, and the 1,3-beta-glucan synthase complex, and is connected to cell wall modification and beta-glucan biosynthesis. Related genes in other species link the family to virulence and pathogenicity.