GST1 — Aspergillus nidulans FGSC A4

Summary

AnGST1 (ANIA_04905) on chromosome 3 of Aspergillus nidulans encodes a glutathione S-transferase with glutathione transferase, glutathione peroxidase, and transcription corepressor activities, and it binds phosphoproteins. The gene is associated with cellular detoxification, nitrate assimilation, regulation of nitrogen utilization, protein urmylation, protein localization, and cellular responses to metal and xenobiotic stimuli. It localizes to the cytoplasm, cytosol, and nucleus. AnGST1 is associated with abnormal mating-type switching, increased cell cycle progression rate, decreased hypoosmotic stress resistance, absent alkaline pH resistance, increased fermentative growth, abnormal respiratory metabolism, increased entry into G0 stationary phase, and sterility. It is also linked to altered carbon source utilization, nutrient uptake, adhesion, pheromone sensitivity, and prion inheritance.