PMC1 — Aspergillus nidulans FGSC A4

Summary

AnPMC1 (ANIA_05088) on chromosome 3 of Aspergillus nidulans encodes a P-type ATPase with potassium:proton, sodium, manganese and calcium transporter activities, as well as ATP hydrolase activity and calcium ion binding. It is associated with the transport of potassium, sodium, calcium and manganese ions, cellular ion homeostasis, cell pH reduction, folate biosynthesis, and the response to unfolded protein. The protein localises to the plasma membrane, vacuolar membrane, Golgi membrane, ER membrane and nuclear envelope. AnPMC1 is linked to calcium sensitivity and numerous phenotypes including abnormal Golgi distribution and morphology, absent or delayed endocytosis, absent spore germination, decreased micronucleophagy, increased ionic stress resistance, and altered vacuolar and protein transport. Studies of related genes in other species connect the family to reduced virulence and pulmonary aspergillosis.