LYSB — Aspergillus nidulans FGSC A4

Summary

AnLYSB (ANIA_05206) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a homoisocitrate dehydrogenase (EC 1.1.1.87) with NAD and magnesium binding activity, belonging to the isopropylmalate dehydrogenase-like domain family. The gene is associated with lysine and leucine biosynthesis, the glyoxylate cycle, the TCA cycle, and isocitrate metabolism, and its product localizes to mitochondria, the mitochondrial lumen, cytoplasm, and cytosol. AnLYSB is associated with abnormal mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy, and mitophagy, reduced respiratory growth and starvation resistance, increased stress and metal resistance, altered competitive fitness, and extended replicative and chronological lifespan. Studies of related genes in other species connect the family to altered invasive growth, heat sensitivity, vacuolar morphology, and chemical compound accumulation.