aldA — Aspergillus nidulans FGSC A4

Summary

ANIA_05435 (aldA) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes an aldehyde dehydrogenase (NAD(+)) with betaine-aldehyde dehydrogenase, acetaldehyde dehydrogenase, and broad aldehyde dehydrogenase [NAD(P)+] activities (EC 1.2.1.3). The protein contains aldehyde dehydrogenase domains and is associated with multiple cellular compartments including the cytoplasm, cytosol, mitochondria, mitochondrial lumen, nucleus, Golgi complex, and extracellular space. This gene is linked to diverse metabolic processes such as carbohydrate utilization, proline metabolism, acetate metabolism, ethanol metabolism, acetaldehyde breakdown, threonine breakdown, polyamine breakdown, and the shikimate pathway. It has also been connected to developmental induction, carbon catabolite repression and activation of transcription, the glucose effect, cellular detoxification of aldehydes and nitrogen compounds, and deubiquitination. Related genes in other species link the family to additional aldehyde dehydrogenase activities (EC 1.2.1.8).