CP1 — Aspergillus nidulans FGSC A4

Summary

ANIA_05442 (CP1, AnCP1) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a serine carboxypeptidase (EC 3.4.16.5) belonging to the peptidase S10 and alpha/beta hydrolase families, with a propeptide carboxypeptidase Y domain. The gene is associated with proteolysis, monocarboxylic acid and antibiotic anabolism, intracellular transport, chromatin organization, methylation, nitric oxide storage, homeostasis, and regulation of gene expression. Its product localizes to the fungal-type vacuole lumen and extracellular. AnCP1 is associated with numerous phenotypes including altered cell death, autophagy, endocytosis, protein secretion, nuclear fusion during mating, prion inheritance, thermotolerance, and Golgi morphology. Related genes in other species connect the family to vacuolar carboxypeptidase function and protein processing.