CRZA — Aspergillus nidulans FGSC A4

Summary

ANIA_05726 (CRZA) on Aspergillus nidulans chromosome 5 encodes a protein with C2H2-type zinc finger domains and is annotated with DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, and 14-3-3 protein binding. The gene is associated with calcineurin-mediated signaling, cellular responses to calcium, copper, cold, acidic pH, and metal ions. It is linked to developmental induction, appressorium formation, regulation of apoptotic processes, biofilm formation, cell-substrate adhesion, bipolar bud site selection, and response to fungi. The product localizes to the nucleus, cytoplasm, cytosol, and chromatin. Related genes in other species are linked to loss of pathogenicity and reduced virulence, as well as associations with fungal meningitis and invasive pulmonary aspergillosis.