apsA — Aspergillus nidulans FGSC A4

Summary

ANIA_05829 (apsA) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a nuclear migration protein with a pleckstrin homology (PH) domain of the Mcp5 type, belonging to the Nuclear_Pos-Cytoskel_Interact family. The product binds tubulin and phospholipids. The gene is associated with nuclear movement, spindle positioning, microtubule nucleation and cytoskeleton organization, as well as actin polymerization, interphase, and nuclear division. It is linked to both asexual and sexual reproduction, including conidiophore development, asexual sporulation, sexual sporulation, and karyogamy. Additional associations include pigment anabolism, host invasion, and maintenance of protein location in the cell cortex. The protein localizes to the cell cortex, plasmalemma, and mitochondria. Related genes in other species are linked to nuclear migration and PH domain-containing proteins.