FLBA — Aspergillus nidulans FGSC A4

Summary

ANIA_05893 (FLBA) in Aspergillus nidulans FGSC A4 encodes a regulator of G-protein signaling (RGS) protein with GTPase-activating protein (GAP) activity, containing RGS, DEP, and winged-helix DNA-binding domains. This gene is associated with the negative regulation of GPCR signaling, asexual sporulation, conidiophore development, fruiting body formation, cleistothecium formation, hyphopodium formation, developmental induction, syngamy, autolysis, amylase release, carbon catabolite repression, pheromone response MAPK cascade, and sterigmatocystin breakdown. It is linked to traits including germination rate and oxidative stress response, and to numerous phenotypes such as altered mating response, pheromone sensitivity, shmoo formation, cell fusion, nuclear fusion during mating, endocytosis, vacuolar transport, vegetative growth, osmotic stress resistance, and sterile outcomes. The protein localizes to the cytoplasm, cytosol, nucleus, and internal side of the plasma membrane.