nudF — Aspergillus nidulans FGSC A4

Summary

ANIA_06197 (nudF) on Aspergillus nidulans FGSC A4 chromosome 1 encodes a dynein regulator LIS1 protein containing LisH and WD40 repeat domains. The gene product binds dynein complexes and microtubule plus-ends, and is associated with microtubule-based transport, nuclear movement, interkinetic nuclear migration, spindle assembly and elongation, mitotic spindle orientation, chromosome separation, microtubule destabilization and sliding, vesicle transport along microtubules, cell migration, ciliogenesis, and sexual sporulation. It localizes to microtubules, spindle pole bodies, kinetochores, and the nuclear envelope. The nudF family is linked through studies of related genes to germination rate and oxidative stress response.