ELO1 — Aspergillus nidulans FGSC A4

Summary

ANIA_06435 (ELO1, AnELO1) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a member of the ELO family of fatty acid elongases, with enzyme activity classified as EC 2.3.1.199. The gene is associated with the elongation of saturated, monounsaturated and polyunsaturated fatty acids, as well as very-long-chain fatty acid and sphingolipid biosynthesis. It has been linked to nuclear membrane organization and localizes to the endoplasmic reticulum, nuclear membrane, cytosol and nucleus. Phenotypic associations include altered cell cycle progression, particularly through the G1/S and M phases, delayed spore germination, abnormal filamentous and pseudohyphal growth, absent cell fusion, defective nucleophagy, and loss of anaerobic and fermentative growth. The gene is also connected to abnormal prion inheritance, telomere length, and mitochondrial genome maintenance. Studies of related genes in other species link the family to calcium sensitivity, acid sensitivity, oxidative stress response, and protein content.