rco-1 — Aspergillus nidulans FGSC A4

Summary

ANIA_06505 (rco-1) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a transcriptional corepressor containing an N-terminal Tup1-like domain and multiple WD40 repeats, with DNA-binding transcription repressor activity, mediator complex binding, histone deacetylase binding, histone binding, GTP binding, and ubiquitin ligase substrate adaptor functions. It is associated with carbon catabolite repression, quorum sensing, the HOG response, regulation of glycogen and isoprenoid metabolism, positive regulation of sterigmatocystin biosynthesis, cleistothecium development, positive regulation of sexual sporulation, phenotypic switching, filamentous growth, mitigation of host defenses, and development of symbiont in host. The protein localizes to the nucleus, cytoplasm, chromatin, transcription repressor complex, SCF complex, and histone methyltransferase complex. Related genes in other species are linked to reduced virulence.