NEO1 — Aspergillus nidulans FGSC A4

Summary

ANIA_06614 (NEO1, AnNEO1) on chromosome 1 encodes a phospholipid-transporting ATPase, a P-type ATPase with flippase and floppase activities for multiple phospholipids and glycolipids, including lysophosphatidylserine, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine, as well as glycoceramide flippase activity and ATPase-coupled intramembrane lipid carrier activity. The gene is associated with phospholipid and ceramide translocation, potassium and sodium ion transport, calcium ion import into vacuoles, endocytic recycling, post-Golgi transport, hyphal growth, and establishment of cell polarity. It localizes to the trans-Golgi network membrane, endosome membrane, division septum, and the Cdc50p-Drs2p complex. Phenotypic associations include abnormal pseudohyphal growth, delayed endocytosis, abnormal Golgi morphology, decreased cell death, increased ionic stress and UV resistance, decreased nutrient uptake, and altered cell cycle progression through G1.