ACUE — Aspergillus nidulans FGSC A4

Summary

ANIA_06653 (ACUE) on chromosome 1 of Aspergillus nidulans encodes a malate synthase (EC 2.3.3.9), a glyoxylate-cycle enzyme with a malate synthase domain. The gene is associated with acetate and fatty acid breakdown, gluconeogenesis, the glyoxylate cycle, carbon catabolite repression, heterotrophy, and methylation. Its product localises to the glyoxysome, peroxisome, and cytoplasm. Phenotypic associations link ACUE to absent innate thermotolerance, altered mitochondrial genome maintenance and morphology, abnormal peroxisomal morphology and transport, increased hyperosmotic stress resistance, decreased spore germination and sporulation, abnormal vegetative growth, increased biofilm formation, decreased cell size, and increased mutation frequency. Studies of related genes in other species connect the family to loss of pathogenicity and decreased filamentous growth.