SWI6 — Aspergillus nidulans FGSC A4

Summary

ANIA_06715 (symbol SWI6, also known as AnSWI6) on chromosome 1 encodes a SWI6-like protein containing a KilA/APSES-type helix-turn-helix DNA-binding domain and ankyrin repeats. The protein exhibits promoter-specific chromatin binding, DNA-binding transcription repressor and activator activities for RNA polymerase II, and transcription coactivator activity. It is associated with the SBF and MBF complexes, localizes to chromatin, cytoplasm, cytosol, and nucleus, and is linked to conidiophore development, conidia and spore formation, cytokinesis, mitosis, cell wall biogenesis, melanin anabolism, autolysis, steroid metabolism, and regulation of G1/S and meiotic cell cycles. The gene is also associated with oxidative stress response. Studies of related genes in other species link the SWI6 family to reduced virulence and associations with turgor pressure and protein content.