BML — Aspergillus nidulans FGSC A4

Summary

ANIA_06838 (BML, also known as AnBML, TUB2, AnNDA3, NDA3, or AnTUB2) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a beta-tubulin protein (tubC) that is a structural constituent of the cytoskeleton, possesses GTPase activity, and binds GTP and metal ions. The gene is associated with microtubule-based processes, supramolecular fiber organization, mitotic spindle organization, mitotic chromosome segregation, and the mitotic cell cycle, as well as conidia and spore formation. It is linked to the response to antibiotics and localizes to microtubules, the tubulin complex, and the cytoplasm. Phenotypic associations include abnormal colony size, cell cycle progression defects (delayed or increased duration in anaphase and metaphase, premature metaphase-anaphase transition), delayed exponential growth, increased polyploidy and aneuploidy, decreased chromosome segregation, and abnormal or absent nuclear fusion during mating. Studies of related genes in other species link the family to resistance to chemicals, altered cold sensitivity, and reduced virulence.