CYS3 — Aspergillus nidulans FGSC A4

Summary

ANIA_07051 (CYS3, metG) on chromosome 4 of Aspergillus nidulans encodes a pyridoxal phosphate-dependent enzyme with O-acetylhomoserine (thiol)-lyase, homocysteine synthase, and cysteine-S-conjugate β-lyase activities (EC 4.4.1.13). The gene is associated with cysteine and methionine biosynthesis, transsulfuration, sulfate assimilation, folate metabolism, and alkaloid metabolism. Its product localises to the cytoplasm, cytosol, nucleus, and peroxisome. Phenotypic associations link CYS3 to abnormal nutrient and sulfur utilisation, altered cell cycle progression (including G1/S and G2/M checkpoints), increased aneuploidy and mitotic recombination, increased UV and X-ray resistance, decreased colony size, absent filamentous growth, and abnormal nucleophagy and mitophagy. Studies of related genes in other species connect the family to oxidative stress response and reduced virulence.