CLM2 — Aspergillus nidulans FGSC A4

Summary

ANIA_07399 (CLM2, AnCLM2) in Aspergillus nidulans FGSC A4 encodes a cytochrome P450 monooxygenase, belonging to the fungal cytochrome P450 family, with oxidoreductase activity acting on paired donors, heme binding, iron binding, and monooxygenase activity. This membrane-associated gene is associated with ergosterol and terpenoid biosynthesis, lipogenesis, mycotoxin production, sexual reproduction, meiosis, fermentation, endocytosis, autophagy, and hypersensitivity. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; abnormal cell cycle progression through G2/M and S phases; increased cell death and fermentative metabolism; arrested vegetative and exponential growth; decreased invasive growth, shmoo formation, and ionizing radiation resistance; and altered utilization of carbon, iron, and phosphorus sources. Studies of related genes in other species connect the family to sterol biosynthesis, particularly through ERG11 and other ERG pathway components.