RPN10 — Aspergillus nidulans FGSC A4

Summary

ANIA_07579 (symbol RPN10, also known as AnRPN10) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes the 26S proteasome regulatory subunit S5A, a member of the PSMD4 family containing a VWF_A domain and ubiquitin-interacting motif (UIM). The gene product is annotated for K48-linked polyubiquitin modification-dependent protein binding and localizes to the proteasome regulatory particle lid and base subcomplexes, as well as the cytosol and nucleus. AnRPN10 is associated with proteasome assembly, proteasomal protein catabolic processes, stalled replication fork localization to the nuclear periphery, mitotic recombination-dependent replication fork processing, and cell differentiation. Phenotypic associations link the gene to decreased spore wall formation, premature apoptosis, altered cell cycle progression (including G2/M phase transition defects and G2 arrest), increased sporulation rate, decreased mitotic recombination, and abnormal vacuolar transport and nucleophagy. Related genes in other species are linked to phosphate content.