SRBA — Aspergillus nidulans FGSC A4

Summary

ANIA_07661 (SRBA, AnSRBA) encodes a bHLH transcription factor with DNA-binding transcription activator activity, SRE binding, protein dimerization activity, and RNA polymerase II-specific cis-regulatory region binding. In Aspergillus nidulans, SRBA is associated with SREBP signalling, regulation of ergosterol biosynthesis, sterol and steroid metabolism, cellular responses to hypoxia, heat, copper, neutral pH, and iron ion homeostasis, as well as filamentous growth, biofilm formation, exocytosis, and symbiotic interactions. The protein localizes to the Sre1-Scp1 complex, endoplasmic reticulum membrane, Golgi membrane, nuclear envelope, chromatin, cytoplasm, and nucleus. Related genes in other species are linked to reduced virulence and associations with pulmonary aspergillosis and disseminated candidiasis.