SSK1 — Aspergillus nidulans FGSC A4

Summary

ANIA_07697 (SSK1, sskA) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a protein with a CheY-like superfamily domain and a signal transduction response regulator receiver domain, possessing histidine kinase, phosphorelay sensor kinase, and phosphorelay response regulator activities. The gene is associated with the HOG response, osmolarity sensing via a two-component system, activation of the p38 cascade, and cellular HOG response. It is linked to regulation of filamentous growth, conidiophore development, germ tube formation, asexual reproduction, and regulation of conidium formation. SSK1 is also associated with upregulation of iron-sulfur cluster assembly, regulation of the cellular response to oxidative stress, and immune evasion. The encoded protein localises to the membrane, cytoplasm, cell division site, and the Mcs4 RR-MAPKKK complex. Studies of related genes in other species link the family to virulence traits including hypervirulence, reduced virulence, and loss of pathogenicity.