apsA — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene apsA (ANIA_07757) on chromosome 4 encodes a protein with a PH domain and a Nuclear_Pos-Cytoskel_Interact domain, and its molecular functions include tubulin binding and phospholipid binding. The gene is associated with numerous fundamental cellular processes, including nuclear movement and positioning, spindle assembly and positioning, microtubule nucleation and cytoskeleton organization, actin polymerization, and karyogamy. It is also linked to both asexual reproduction (conidiophore development and asexual sporulation) and sexual reproduction (sexual sporulation), as well as pigment anabolism and host invasion. The encoded protein localizes to the cell cortex, plasma membrane, and mitochondria. Studies of related genes in other species link the ApsA family to nuclear migration.