mirA — Aspergillus nidulans FGSC A4

Summary

ANIA_07800 (mirA) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a major facilitator superfamily (MFS) transporter with enterochelin and iron-siderophore transporter activity. The gene is associated with siderophore anabolism and its regulation, ferric triacetylfusarinine C import, ornithine metabolism, cellular response to iron ion starvation, iron transport and homeostasis, nitric oxide storage, detoxification, membrane transport, and cell death. The encoded protein localises to the plasma membrane, cytoplasmic vesicle membrane, endosome, vacuolar membrane, fungal-type vacuole membrane, and cell tip. Studies of related genes in other species link the family to siderophore-iron import and reduced virulence.