CLR3 — Aspergillus nidulans FGSC A4

Summary

ANIA_08042 (symbol CLR3, also known as AnHDA1) on chromosome 2 of Aspergillus nidulans encodes a protein with histone H3-K9, H3-K14, H4-K5, H4-K8, H4-K12, and H4-K16 deacetylase activities (EC 3.5.1.98). The protein contains an Arb2 domain and a histone deacetylase domain, and it binds chromatin and identical proteins. CLR3 is associated with the regulation of secondary metabolite biosynthesis, including inhibition of penicillin anabolism and regulation of sterigmatocystin production. It is linked to epigenetic gene silencing, heterochromatin island and rDNA heterochromatin assembly, centromeric silencing, and silent mating-type cassette chromatin silencing. The gene is also associated with filamentous growth in response to pH, appressorium formation, and phenotypic switching. CLR3 localises to the HDA1 complex, HDAC complex, Rpd3S, SET3C, euchromatin, and heterochromatin. Phenotypic associations include altered mating-type switching, sporulation rate, carbon source utilisation, cell cycle progression, and desiccation resistance.