ELO1 — Aspergillus nidulans FGSC A4

Summary

ANIA_08117 (ELO1, AnELO1) encodes a member of the ELO family of fatty acid elongases, with enzyme activity 2.3.1.199 (ELOVL). In Aspergillus nidulans, the gene is associated with the elongation of saturated, monounsaturated and polyunsaturated fatty acids, as well as very-long-chain fatty acid and sphingolipid anabolism. The encoded protein localises to the endoplasmic reticulum and nuclear membrane, and is linked to nuclear membrane organisation. Phenotypic associations connect ELO1 to cell cycle progression, particularly G1/S phase transition, spore germination, filamentous growth, cell fusion, and mitochondrial transport and genome maintenance. The gene has also been associated with thermotolerance, respiratory and fermentative growth, and nucleophagy. Studies of related genes in other species link the ELO1 family to calcium and acid sensitivity, oxidative stress response, and protein content.