PMB — Aspergillus nidulans FGSC A4

Summary

ANIA_08279 (symbol PMB, also known as AnPMB and ALP1) on Aspergillus nidulans chromosome 2 encodes a basic amino acid transporter belonging to the APC/YAT family of amino acid permeases. The encoded protein exhibits amino acid binding activity and is a transmembrane transporter for L-arginine, L-lysine, L-histidine, and L-proline. It is associated with basic amino acid transport, proline import, amino acid membrane transport, filamentous growth, single-species biofilm formation, and the meiotic cell cycle. The protein localises to the plasma membrane, eisosome, fungal-type cell wall, Golgi complex, and endoplasmic reticulum. Phenotypic associations include abnormal nitrogen source utilisation, altered cell cycle progression, decreased nutrient uptake, increased freeze-thaw resistance, decreased apoptosis, and abnormal plasma membrane morphology. Studies of related genes in other species link the family to biofilm formation, stress resistance, and chronological lifespan.