PMC1 — Aspergillus nidulans FGSC A4

Summary

AnPMC1 (ANIA_08399) on chromosome 5 of Aspergillus nidulans encodes a P-type ATPase of the IIB subfamily with P-type potassium:proton transporter activity, K+-transporting ATPase activity, and additional annotations for sodium, manganese, and calcium transporter activities. The gene is associated with potassium ion export, sodium transport, calcium transport, manganese ion membrane transport, proton export across the plasma membrane, and cellular pH regulation. It is also linked to folate biosynthesis, response to unfolded protein, and localisation at the plasma membrane, vacuolar membrane, Golgi membrane, ER membrane, and nuclear envelope. Associations include calcium sensitivity, abnormal Golgi distribution and morphology, absent spore germination, decreased micronucleophagy, increased ionic stress resistance, and altered endocytosis, vacuolar transport, and protein transport. Related genes in other species link the family to calcium-transporting ATPase activity and reduced virulence.