CYS2 — Aspergillus nidulans FGSC A4

Summary

ANIA_08565 (CYS2, AnCYS2) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes a protein with an alpha/beta hydrolase fold and a HAT_MetX-like domain that possesses L-serine O-succinyltransferase, L-serine O-acetyltransferase, deacetylcephalosporin-C acetyltransferase, and homoserine O-acetyltransferase activities (EC 2.3.1.-). The gene is associated with cysteine and antibiotic anabolism, homoserine metabolism, nicotinate breakdown, terpenoid anabolism, and asexual reproduction. The encoded protein localises to the mitochondria and mitochondrial lumen. Studies of related genes in other species link the family to homoserine O-acetyltransferase activity (EC 2.3.1.31 and 2.3.1.175) and, in maize, to ear and stalk rot without affecting pathogenicity.