MTFA — Aspergillus nidulans FGSC A4

Summary

ANIA_08741 (MTFA, AnMTFA) on chromosome 3 of Aspergillus nidulans encodes a C2H2 zinc-finger domain protein with DNA-binding transcription repressor activity specific to RNA polymerase II. The protein localises to the nucleus and binds zinc. AnMTFA is associated with the positive regulation of conidiophore and cleistothecium development, sterigmatocystin biosynthesis, penicillin metabolism, and terrequinone A biosynthesis. It is also linked to cellular zinc ion homeostasis, regulation of secondary metabolism, mycotoxin anabolism, morphogenesis, and negative regulation of transcription by RNA polymerase II. Related genes in other species connect the family to developmental and secondary metabolic processes.